德国慢性髓性白血病患者的治疗期望和目标:以患者为中心的视角
Philipp Ernst1, Cera Lohse2,3, Michael Lauseker4
1Klinik für Innere Medizin II, Universitätsklinikum Jena, Comprehensive Cancer Center Central Germany, Campus Jena, Jena, Germany. philipp.ernst@med.uni-jena.de.
Leukemia
|December 19, 2025
概括
了解慢性髓性白血病 (CML) 治疗中的患者优先事项至关重要. 德国的CML患者重视耐受性和生活质量,优先级因年龄和治疗史而异.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 患者报告的结果
背景情况:
- 慢性髓性白血病 (CML) 的管理已经显著改善了氨酸激酶抑制剂 (TKI) 治疗,导致了优秀的长期生存.
- 尽管治疗方面取得了进展,但对于患者对CML治疗目标和生活质量 (QoL) 的优先事项缺乏全面的了解.
研究的目的:
- 调查德国CML患者在不同疾病阶段的治疗目标和QOL优先级:诊断,治疗和无治疗缓解 (TFR).
- 探索年龄,疾病持续时间和治疗史等因素如何影响患者的偏好.
主要方法:
- 在德国582名CML患者中进行了全国性的在线调查 (2024年11月至2025年2月),与患者组织合作.
- 该调查使用了经过验证的工具来确定治疗满意度,治疗进展的恐惧和生活质量优先级,以及新开发的问题.
主要成果:
- 一般来说,TKI耐受性被评为积极的,特别是在治疗早期阶段. 长期幸存者报告了更多的日常生活限制.
- 年轻的患者 (<45岁) 优先考虑生育,性和工作,而老年患者则专注于耐受性,独立性和心理健康.
- 之前有TKI停药经验的患者表现出更愿意接受缓解的不良事件.
结论:
- 患者在CML治疗中的优先事项各不相同,通常涉及深层分子反应和最佳耐受性之间的权衡.
- 将患者报告的偏好纳入共享决策是提高CML护理的满意度,坚持和长期结果的关键.
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