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Updated: Jan 8, 2026

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors
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基于BET抑制剂的组合,针对MECOM重新安排的 (r) AML中的新型依赖性

Christine E Birdwell1, Warren Fiskus1, Christopher P Mill1

  • 1The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, USA.

Leukemia
|December 19, 2025
PubMed
概括

在急性髓性白血病 (AML) 中的MECOM重组驱动了疾病的攻击性. 将BET抑制剂与PI3K/mTOR或IAP抑制剂相结合,在MECOM重排的AML模型中显示出更高的疗效.

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