异常的STING信号促进了糖尿病视网膜病变中的内皮功能障碍和神经血管损伤
Xinran Qin1, Shuli Chen1, Yu Sun2
1Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetologia
|December 19, 2025
概括
糖尿病视网膜病变涉及由内皮细胞中的STING通路驱动的炎症. 抑制这种途径对糖尿病眼病的早期治疗干预有前途.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因,其特点是视网膜神经血管功能障碍和炎症.
- 干扰素基因刺激 (STING) 途径与炎症性疾病有关,但其在DR中的作用尚未完全理解.
研究的目的:
- 研究糖尿病视网膜病变中STING通路的细胞特异性功能.
- 评估STING作为DR的潜在早期干预目标.
主要方法:
- 分析来自人类和小鼠视网膜的单细胞RNA测序数据集.
- 建立一种2型糖尿病小鼠模型来评估STING表达和局部化.
- 在体内和体外实验中使用遗传删除或药理上抑制STING的实验.
主要成果:
- 在糖尿病视网膜 (人类和小鼠) 的内皮细胞中观察到增加的STING表达和干扰素 (IFN) 信号.
- 糖尿病诱导的STING激活和下游信号 (TBK1酸化),特别是在内皮细胞中.
- 在糖尿病小鼠中,STING抑制显著降低了视网膜炎症和神经血管功能障碍.
结论:
- 对cGAS/STING/IFN通路的内皮特异性激活是DR病原发生的一个关键因素.
- 准STING通路为糖尿病视网膜病变早期干预提供了潜在的治疗策略.
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