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Updated: Jan 8, 2026

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
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Published on: April 16, 2021

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多路线分析确定与大动脉功能和大动脉狭窄风险相关的遗传变异.

Shinwan Kany1,2,3,4, Joel T Rämö1,5,6, Cody Hou1,7

  • 1Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature genetics
|December 19, 2025
PubMed
概括

遗传因素影响大动脉膜功能和大动脉狭窄风险. 这项研究确定了166个基因位置,并证实了PCSK9和LDLR的作用,表明了预防大动脉狭窄的潜在治疗点.

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