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干扰素治疗引起的PD-1+CD8+和CD160+CD8+T细胞的减少与B型肝炎的功能治愈有关

Daqiong Zhou¹, Jiangyu Liu¹, Jianru Jia²

¹Beijing Youan Hospital, Capital Medical University, No.8, Xitou Alley, Outer, You'an Gate, Fengtai, Beijing, China.

BMC infectious diseases

|December 19, 2025

概括

在一些HBeAg阴性患者中,Pegylated干扰素-α (Peg-IFN-α) 治疗可能导致B型肝炎表面抗原 (HBsAg) 清除. 这种治疗与改善T细胞功能和减少T细胞耗尽有关,这表明慢性乙型肝炎的潜在功能治疗方法.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
病毒学病毒学

背景情况:

乙型肝炎病毒 (HBV) 感染是一个全球性的健康问题.
乙型肝炎表面抗原 (HBsAg) 血清清除意味着慢性HBV的功能治愈.
化干扰素-α (Peg-IFN-α) 是慢性HBV的治疗选择.

研究的目的:

评估Peg-IFN-α在实现HBeAg阴性患者的HBsAg血清清除中的疗效.
研究Peg-IFN-α治疗与T细胞亚群动态之间的关联.

主要方法:

对618名慢性HBV患者的回顾性分析.
34名接受Peg-IFN-α治疗的HBeAg阴性患者的长度免疫分析.
对T细胞群 (CD4+,CD8+,TCM,TEMRA,Th2) 和疲劳标记 (PD-1,CD160) 的分析.

主要成果:

在34.6%的患者中,HBsAg清除得到了实现.
受访者显示CD4+ TCM增加,CD8+ TCM稳定,CD8+ TEMRA和Th2细胞减少.
受访者表现出PD-1+和CD160+CD8+T细胞的显著减少,表明T细胞枯竭的逆转.

结论:

-IFN-α可以促进HBsAg清除在选择的HBeAg阴性患者.
低基线HBsAg水平和年轻的年龄与更好的反应有关.
部分可逆的T细胞耗尽是治疗成功的关键因素.

关键词:

慢性乙型肝炎病毒感染.在HBsAg血清清除过程中,抑制性受体的受体对于T细胞免疫的免疫力.T细胞子集是T细胞的子集.

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