相关实验视频

Updated: Jan 8, 2026

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

与乳腺癌患者发展和存活大脑转移相关的因素:多中心体验

Ahmad Alhalabi¹, Theresa Abdo², Ali Hijazi²

¹Department of Hematology and Oncology, Maroone Cancer Center, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA. alhalaa2@ccf.org.

|December 19, 2025

概括

乳腺癌与大脑转移 (BCBM) 的存活率通过向治疗,手术和特定的辐射技术得到改善. 预测模型应该整合治疗数据,以便更好地预测.

科学领域:

在瘤学瘤学.
神经瘤学神经瘤学
临床研究临床研究

背景情况:

经过大脑转移的乳腺癌 (BCBM) 带来了重大的生存挑战.
目前对BCBM的预后工具可能无法完全捕捉现代治疗的影响.

研究的目的:

为了确定BCBM患者的生存预测因素.
评估乳腺分级预后评估 (B-GPA) 工具及其变量的作用.
评估新兴向治疗对BCBM生存结果的影响.

主要方法:

在2010-2020年间诊断的318名BCBM患者的回顾性审查.
人口,临床和治疗变量的收集,包括全身疗法和大脑转移特征.
使用卡普兰-梅尔和考克斯回归模型进行生存分析.

主要成果:

三重阳性BC亚型的整体存活时间 (mOS) 比三重阴性更长.
更少的额外头转移 (ECM) 和使用HER2向治疗,PARP抑制剂和TKI与较长的mOS相关.
大脑手术和立体射线手术 (SRS) 显著改善了mOS.

结论:

BCBM的结果是异质的,并受到疾病负担,年龄,表现状况和特定治疗的影响.
新型向疗法,脑外科手术和SRS在改善BCBM患者的长期结果方面显示出希望.
应更新BCBM的预后模型,以纳入治疗暴露,以便进行动态的,知情的预后.

关键词:

大脑转移的转移.乳腺癌是什么? 乳腺癌是什么总体生存率总体生存率

更多相关视频

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

相关概念视频

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...