系统性炎症反应指数:一种新的预测器,用于心血管疾病的风险,在患者的初级胆道胆炎
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing, 100029, China.
European journal of medical research
|December 19, 2025
概括
系统性炎症反应指数 (SIRI) 是一项有前途的心血管疾病 (CVD) 生物标志物,用于原发性胆道胆炎 (PBC) 患者. 较高的SIRI水平独立预测心血管疾病风险增加,有助于临床风险分层.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 心血管疾病 (CVD) 对患有原发性胆道胆炎 (PBC) 的患者构成重大风险.
- 在PBC中免疫失调和慢性炎症有助于增加心血管疾病风险.
- 传统的CVD生物标志物在PBC群体中可能缺乏预测准确性.
研究的目的:
- 研究在被诊断为PBC的患者中炎症生物标志物和心血管疾病之间的关联.
- 评估CVD炎症生物标志物的预测价值在这个特定的患者队列.
主要方法:
- 在北京迪坦医院 (2018-2022) 接受治疗的PBC患者的回顾性分析.
- 多变量逻辑回归模型评估了SIRI,SII,NLR,MLR和CVD之间的关系.
- 接收器操作特征 (ROC) 曲线评估了预测性能;受限立方线 (RCS) 分析探索了SIRI-CVD关系.
主要成果:
- 在PBC患者中,心血管疾病的患病率为16.9%.
- 系统性炎症反应指数 (SIRI) 被确定为心血管疾病的独立风险因素.
- 每次SD增加的SIRI与79.2%的心血管疾病风险增加相关 (OR=1.792).
- 与NLR,MLR和SII相比,SIRI显示出更高的预测能力 (AUC=0.725).
- 观察到SIRI和心血管疾病之间的线性关联,SIRI风险增加>0.65.
结论:
- SIRI是预测PBC患者心血管疾病的有价值的炎症生物标志物.
- 在各种子组中,SIRI和心血管疾病风险之间的关联仍然很强,除了老年和肝硬化.
- 将SIRI纳入临床实践可以增强心血管疾病风险分层,并指导PBC患者的预防策略.
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