长期的DNA甲基化变化是由年龄和骨肌肉中CO2升高引起的
Joseph Balnis1,2, Andy Madrid3, Emily L Jackson1,2
1Division of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY, USA.
Skeletal muscle
|December 19, 2025
概括
升高的二氧化碳 (CO2) 会导致长期的骨肌肉消耗和DNA甲基化变化,这些变化与衰老无关. 这种肌肉功能障碍即使在恢复到正常的二氧化碳水平后仍然存在.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 骨肌肉生理学 骨肌肉生理学
- 肺部疾病研究研究
背景情况:
- 骨肌肉功能障碍和高头 (CO2升高) 与肺部疾病中的死亡率有关.
- 衰老,高头和自功能障碍共享重叠的骨肌肉表型.
- 以前对骨肌肉中的DNA甲基化进行的研究范围有限;缺乏对CO2和年龄引起的变化的全基因组比较.
研究的目的:
- 为了比较分析全基因组DNA甲基化和基因表达的变化,骨肌的肌肉诱导的超与衰老.
- 为了调查超肌引起的骨肌肉变化的持续性.
- 探索由超引起的表观遗传修饰的潜在机制,包括自和基质平衡.
主要方法:
- 全基因组甲基化测序 (WGMS) 和RNA测序在暴露于normo-和hypercapnia的小鼠和老年小鼠身上进行.
- 对DNA甲基化和转录表达的比较分析在超和衰老之间重叠.
- 骨肌特异性自性遗传切除和质谱学被用来调查机制.
主要成果:
- 超症诱导了异常的DNA甲基化模式和骨肌肉中的肌纤维类型变化.
- 肌肉质量恶化持续甚至在返回normocapnia后.
- 二氧化碳诱导的DNA甲基化变化与与年龄相关的表观遗传变化没有重叠.
- 超症并没有通过自或基质失衡影响甲基组.
结论:
- 超症诱导了与中断的甲基瘤相关的持续性骨肌肉损耗.
- 二氧化碳诱导的表观遗传变化与与年龄相关的变化不同,并且独立于自和基质调节.
相关概念视频
01:37Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
01:46Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
01:37Mitochondria
19.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.5K
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
02:23Master Transcription Regulators
7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
01:13Formation of Muscle Fibers from Myoblasts
5.7K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.7K