在西班牙,基于人口的甲状腺功能障碍的国家发病率
Silvia Patricia Alonso1,2, Natalia Colomo3,4,5,6, Ana Lago-Sampedro7,8,9
1Department of Endocrinology and Nutrition, Hospital Costa del Sol. Marbella (Málaga), Marbella, Spain.
Scientific reports
|December 19, 2025
概括
这项研究揭示了西班牙甲状腺功能障碍的发病率,甲状腺功能障碍每1000人年影响13.38人. 女性性别和高甲状腺刺激激素 (TSH) 水平是甲状腺功能低下症的关键危险因素.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 甲状腺功能障碍是一种普遍的健康问题,地理发病率数据有限.
- 了解发病率和风险因素对于公共卫生战略至关重要.
研究的目的:
- 为了确定成年西班牙人口中甲状腺功能障碍的发生率.
- 为了确定与甲状腺功能障碍的出现相关的因素.
主要方法:
- 全国范围的观测性基于人口的队列研究,对1629名非甲状腺成年人进行了观察.
- 基线评估 (2008-2010) 与后续评估 (2016-2017) 进行.
- 多变量物流回归和ROC分析用于风险因素和预测切线识别.
主要成果:
- 甲状腺功能低下症的发生率:13.38/1,000人/年 (TSH ≥5 mIU/mL) 和6.78/1,000人/年 (TSH ≥10 mIU/mL).
- 甲状腺功能障碍的发病率:每年2.65/1,000人.
- 甲状腺功能低下的独立预测因素:女性性别,年龄 (30-40,>60岁),TPOAb (>20 mIU/L) 和TSH (>2.8 mIU/mL) 的升高.
结论:
- 这项研究提供了西班牙甲状腺功能障碍的基本发病率数据.
- 确定了关键的风险因素,包括女性的性别,年龄和特定的TPOAb和TSH水平.
- 确立了TPOAb (9.1 mIU/L) 和TSH (2.03 mIU/mL) 的预测截止值,用于发生的甲状腺功能低下症.
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