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Updated: Jan 8, 2026

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突变CHCHD10破坏了细胞染色体c的氧化,并激活了线粒体逆行信号

Márcio Augusto Campos-Ribeiro1, Erminia Donnarumma1, Hendrik Nolte2

  • 1Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France.

EMBO molecular medicine
|December 19, 2025
PubMed
概括

在CHCHD10突变导致线粒体疾病通过损害铜平衡和应激适应. 这项研究揭示了CHCHD10聚合如何破坏线粒体蛋白质稳定,导致心肌病并提供新的治疗点.

关键词:
在CHCHD10中使用CHCHD10心肌病是一种心肌病.细胞染色体c 在线粒体疾病 线粒体疾病一个OMA1一个OMA1一个OMA1

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