通过 Lim1-介导的神经钟的加速来适应温暖的环境
Zhihua Liu1,2, Dapeng Xie1, Stephen X Zhang2
1State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, China.
Nature neuroscience
|December 19, 2025
概括
环境温度会影响Drosophila的昼夜时钟速度. 一个特定的路径加速时钟在26°C以上,使行为适应而不损害计时可靠性.
科学领域:
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 循环时钟保持生物计时,但对温度波动敏感.
- 分子时钟周期会随着温度的增加而显著加速,从而损害了可靠的计时.
- 尽管存在热缓冲,但行为周期显示温度依赖的时间变化.
研究的目的:
- 调查行为周期中温度依赖转变背后的机制.
- 为了确定时钟本身是否会随着神经元的温度而变化.
- 为了确定分子路径调节时钟速度响应温度.
主要方法:
- 使用Drosophila melanogaster作为一个模型生物.
- 在不同的环境温度下监测行为周期.
- 研究了基因表达和神经元通路,重点关注LIM-家庭主体转录因子.
主要成果:
- 证明温度直接影响神经元中昼夜时钟的速度.
- 确定了一条对温度敏感的途径,涉及转录因子Lim1,该转录因子在~26°C以上加速时钟速度.
- 观察到,加快时钟速度导致Drosophila早上早起.
结论:
- 温度依赖的行为周期时间由神经元时钟速度的变化解释.
- 一个Lim1-介导的途径允许Drosophila钟加速,促进行为热适应.
- 这种调节的加速度机制将行为适应温度,而不会影响整体昼夜计时的准确性.
相关概念视频
Biological Clocks and Seasonal Responses
41.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.4K
Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
Responses to Heat and Cold Stress
14.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.6K
Background and Environment Affect Phenotype
7.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.4K


