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周围和肝脏B细胞子集有助于慢性乙型肝炎患者的HBeAg血清转化

Jing Zuo^1,2, Xue-Qi Yang^1,2, Fang-Ming Zhou³

¹Department of Hepatology, Qilu Hospital of Shandong University, Jinan, 250012, China.

Virology journal

|December 20, 2025

概括

了解B细胞动态是治疗慢性乙型肝炎 (CHB) 的关键. 这项研究揭示了B细胞子集如何影响HBeAg血清转化和HBV持久性,为功能治疗策略提供了洞察力.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
细胞生物学细胞生物学

背景情况:

慢性乙型肝炎 (CHB) 病原发生涉及复杂的免疫阶段,阻碍功能治愈.
对于HBeAg阳性 (HBeAg+) 患者,持续的HBeAg血清转化是主要的治疗目标.
在HBeAg血清转化过程中,B细胞子集的动态尚不清楚.

研究的目的:

用单细胞测序分析CHB患者在HBeAg血清转化期间分析B细胞子集动态.
研究B细胞子集在限制HBsAg血清转化中的作用.
为了阐明B细胞子集的功能缺陷,有助于HBV持久性.

主要方法:

从GEO数据库中检索并集成了scRNA-seq数据集 (GSE182159,GSE234241).从GEO数据库中检索和集成了scRNA-seq数据集 (GSE182159,GSE234241).从GEO数据库中检索和集成了scRNA-seq数据集 (GSE182159,GSE234241) 从GEO数据库中检索和集成了scRNA-seq数据集.
分析了来自HBeAg阳性,HBeAg阴性CHB患者,健康对照和慢性已解决病例的外周血液和肝脏样本.
进行了B细胞子集分布和功能特征的比较分析.

主要成果:

在HBeAg阳性和HBeAg阴性CHB患者中观察到天真和记忆B细胞的相反分布趋势.
与对照组相比,HBeAg阴性CHB患者的血细胞比例下降和肝脏B细胞记忆增加.
HBeAg阳性CHB患者的B细胞子集表现出更严重的代谢和表观遗传缺陷,而HBeAg阴性患者表现出能量代谢和免疫激活受损.

结论:

B细胞子集在HBeAg血清转化中发挥着关键作用.
B细胞子集的比例变化和功能缺陷有助于HBV感染的持续性.
针对B细胞子集功能障碍可能是实现CHB功能治愈的策略.

关键词:

B 细胞 B 细胞 B 细胞慢性乙型肝炎 (CHB) 是一种乙型肝炎病毒清除时间在 HBeAg 血清转化过程中.有HBeAg阴性 (HBeAg−) 慢性HBV感染.

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