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SARS-CoV-2亚变体对老年关节骨折患者的术后结果的影响 - 一项跨国多中心研究

Gregor Toporowski¹, Christian M Mueller-Mai², Katherine Rascher³

¹Department of General Orthopaedics and Tumour Orthopaedics, Muenster University Hospital, Albert-Schweitzer-Campus 1, Muenster, 48149, Germany. Gregor.Toporowski@ukmuenster.de.

|December 20, 2025

概括

部骨折手术结果因COVID-19变种而异. 虽然Alpha变种的死亡率相似,但Delta和Omicron变种与更高的死亡率和更长的COVID-19阳性患者住院时间有关.

科学领域:

老年创伤医疗的创伤学
传染性疾病传染性疾病
外科手术的结果

背景情况:

骨折 (HF) 在老年人中很常见,在COVID-19大流行期间的发病率仍然很高.
SARS-CoV-2 感染复杂化HF病例,增加死亡率和住院时间.
这项研究调查了SARS-CoV-2变种 (阿尔法,三角形,欧米克朗) 对高风患者手术后结果的影响.

研究的目的:

评估不同SARS-CoV-2亚变体对关节骨折患者手术结果的影响.
为了在不同变种期间比较COVID-19阳性和阴性患者之间的术后死亡率和住院时间.

主要方法:

一项回顾性多中心研究利用了2021年3月至2022年4月的德国老年创伤登记处 (ATR-DGU®) 的数据.
分析了12707名接受关节骨折手术的患者,根据主要的SARS-CoV-2亚变体时期 (阿尔法,三角形,欧米克朗) 和COVID-19状态分层.
根据住院死亡率,住院时间,骨折前的流动性和制度化率,对象队列进行了比较.

主要成果:

在阿尔法变种期间,COVID-19阳性和阴性患者的住院死亡率和住院时间长度相似.
在三角洲和欧米克朗时期,COVID-19阳性患者的死亡率显著增加 (14.3%和13.9%) 和住院时间更长 (17vs15天),与SARS-CoV-2阴性患者相比.
COVID-19阳性患者更频繁地住院,并且在骨折前的运动能力降低.

结论:

在阿尔法变种阶段,COVID-19并发症与较低的死亡率有关,但在Delta和Omicron阶段的死亡率较高.
总体而言,COVID-19阳性显著增加了住院死亡率和关节骨折患者的长期住院时间.
未测量的混因素可能会影响这些观察结果.

关键词:

在 COVID-19 疫情中,部骨折部骨折部骨折整形老年病的管理靠近大腿骨骨折靠近大腿骨骨折这就是SARS-CoV-2病毒.

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