结构性和功能性MRI在预测多发性硬化症中对运动训练的反应中的贡献
Tetsu Morozumi1, Paolo Preziosa2, Alessandro Meani3
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
概括
多发性硬化症 (MS) 的白质管道完整性预测了运动反应. 神经成像可以确定MS患者谁将从有氧训练等康复计划中受益最多.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 神经成像是一种神经成像.
背景情况:
- 有氧训练显示出多发性硬化症 (MS) 康复的前景.
- 个体患者对MS运动干预措施的反应是高度可变的.
研究的目的:
- 为了确定基线人口,临床和MRI特征是否预测MS患者对有氧或非有氧训练的反应.
- 确定特定的神经成像生物标志物用于MS的运动反应.
主要方法:
- 88名多发性硬化患者被随机分配到有氧或非有氧训练组.
- 响应被定义为在6分钟步行测试中改善≥21.6米.
- 随机森林模型分析了基线MRI (WM完整性,病变负载,体积) 和临床数据,以预测训练反应.
主要成果:
- 在有氧组中,反应的预测因素包括皮质脊髓管 (CST) 和中小脑 (MCP) 分数异构.
- 上大脑小脚 (SCP) 的平均扩散度预测了非有氧组的反应.
- CST,MCP和SCP扩散度指标集体预测了整个MS队列的训练反应,具有验证的预测准确性 (AUC0.648-0.672).
结论:
- 运动相关白质 (WM) 航道的微结构完整性是MS中运动训练反应的关键预测因素.
- 神经成像在个性化康复策略方面发挥着至关重要的作用,通过识别可能受益于特定运动干预措施的多发性硬化患者.
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