危重病患者发生德克斯梅德托米丁相关发烧的危险因素
Hyun A Jae1, Karina Muzykovsky1, Jose Orsini2
1Department of Pharmacotherapy, The Brooklyn Hospital Center, Brooklyn, NY, USA.
Journal of pharmacy practice
|December 20, 2025
概括
在接受德克斯梅托米丁输液的危急病患者中可能出现发烧. 风险因素包括持续输注72小时或更长时间和更高的输注率,这可能导致误诊和不必要的治疗.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 临床实践指南 临床实践指南
背景情况:
- 危急护理医学协会建议用德克斯梅德托米丁治疗危急病的机械通风患者.
- 发烧是德克斯梅德托米丁的副作用,通常是排除诊断.
- 错误诊断药物引起的发烧可能会导致资源利用率增加.
研究的目的:
- 为了确定危重病患者中与德克斯梅德托米丁相关的发烧的危险因素.
- 为了改善对德克斯梅德托米丁诱导的发烧的识别和治疗.
- 为了向临床实践提供关于德克斯梅德托米丁使用的信息.
主要方法:
- 布鲁克林医院中心的单中心回顾性研究.
- 包括成人ICU患者,接受连续12小时或更长时间的德克斯梅德托米丁输液.
- 使用单变量和多变量逻辑回归来识别风险因素.
主要成果:
- 在81名患者中,有38.3%的患者在注射德克斯美德托米丁时发烧.
- 连续输注德克斯梅德托米丁≥72小时增加了发烧风险 (OR 5.97).
- 在Tmax时,德克斯梅德托米丁输液速率≥1mcg/kg/hr增加了发烧风险 (OR 6.16).
结论:
- 长时间的德克斯梅德托米丁输液 (≥72小时) 是发烧的危险因素.
- 较高的德克斯梅德托米丁输液率 (≥1mcg/kg/hr) 与发烧有关.
- 这些发现有助于识别患有德克斯梅德米丁相关发烧风险的患者.
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