脂质体布皮瓦卡因可以减少术后阿片类药物在基于组织扩展器的乳房重建中的使用吗?
Thomas Ren1, Andre Galenchik-Chan2, Nicolas Oltean2
1Renassaince School of Medicine, Stony Brook University, Stony Brook, NY, USA. thomas.ren@stonybrookmedicine.edu.
Aesthetic plastic surgery
|December 20, 2025
概括
与Marcaine相比,Exparel在乳腺重建患者中显著减少了阿片类药物的使用. 这种手术后增强恢复 (ERAS) 方法可能会降低与阿片类药物疼痛管理相关的风险.
科学领域:
- 整形外科 整形外科 整形外科
- 麻醉学 麻醉学
- 疼痛管理 疼痛管理
背景情况:
- 在乳房重建中术后使用阿片类药物具有显著的副作用.
- 手术后增强恢复 (ERAS) 协议的目的是尽量减少阿片类药物消费.
- 区域麻醉阻塞是ERAS协议的关键组成部分.
研究的目的:
- 为了比较Exparel与Marcaine在减少术后阿片类药物使用方面的有效性.
- 为了评估脂质体布皮瓦卡因对乳房重建后疼痛管理的影响.
主要方法:
- 对163名乳房重建患者 (2019年1月至2022年6月) 的回顾性研究.
- 患者接受了马卡因或埃克斯帕雷尔用于区域麻醉.
- 追踪了阿片类药物处方,并将其转换为吗啡等效剂量 (MED).
主要成果:
- 埃克斯帕雷尔组的阿片类药物消费显著降低 (97.21 ± 81.77 MED) 与马卡因组 (160.53 ± 150.58 MED) 相比.
- 埃克斯帕雷尔组的阿片类药物处方总数较少 (1.35对1.90).
- 根据乳房重建类型,没有发现显著差异.
结论:
- 在乳房重建中,埃克斯帕雷尔与马卡因相比,显著降低了术后阿片类药物需求.
- 这一发现支持Exparel在乳房重建ERAS协议中的作用.
- 使用Exparel可以改善患者的康复,并减轻与阿片类药物相关的不良事件.
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