慢性鼻炎的急性恶化
Robert M Frederick1, Kent Lam1, Joseph K Han2
1Department of Otolaryngology - Head & Neck Surgery, EVMS Otolaryngology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, 600 Gresham Dr. Suite 1100, Norfolk, VA, 23507, USA.
Current allergy and asthma reports
|December 20, 2025
概括
慢性鼻炎 (AECRS) 的急性恶化更好地通过症状持续时间和治疗变化来定义,而不仅仅是患者报告的药物使用. 了解AECRS病理生理学和患者风险因素对于适当的治疗至关重要.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 慢性鼻炎 (CRS) 是上呼吸道的复杂炎症状况.
- 慢性鼻炎的急性恶化 (AECRS) 是一个重大的临床挑战.
- 以前的AECRS定义缺乏标准化,阻碍了研究和临床实践.
研究的目的:
- 审查了解AECRS.的演变表型的最新进展.
- 专注于澄清AECRS病理生理学,患者特征和疾病负担的研究.
- 突出AECRS研究和临床翻译的正式定义的重要性.
主要方法:
- 对AECRS.最近研究的文献综述.
- 对AECRS不断变化的定义和诊断标准的分析.
- 对AECRS病理生理学,危险因素和治疗模式的研究进行审查.
主要成果:
- 最近对AECRS的监管定义要求>3天的症状恶化和治疗升级.
- 患者报告的救援药物使用频率对于定义AECRS发作是不可靠的.
- AECRS病理生理学可能涉及由病毒侮辱引发的鼻腔微生物组失调,导致细菌感染.
- 患有喘和/或过敏性鼻炎的CRS患者有AECRS的风险增加.
- 对AECRS的抗生素和皮质类固醇的过度处方是常见的,增加了医疗保健成本和风险.
结论:
- 对AECRS的正式定义对于可翻译的研究和改善的临床结果至关重要.
- 了解CRS,喘和过敏性鼻炎之间的相互作用是管理AECRS的关键.
- 在AECRS管理中减轻过度使用抗生素和皮质类固醇对于对抗抗生素耐药性和不良影响至关重要.
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