孕产妇维生素B状态和补充对儿童神经发育和认知的影响:系统性审查
Dandara Baia Bonifácio1, Francielle Barbosa Pena1, Kelly Aparecida Dias1
1Department of Nutrition and Health, Universidade Federal de Viçosa, Avenida PH Rolfs, s/n. Viçosa, Viçosa, MG, 36570-900, Brazil.
Current nutrition reports
|December 20, 2025
概括
母亲的维生素B12补充和状态影响孩子的认知和语言发展,长达42个月. 确保母亲获得足够的维生素B12对于健康的神经发育至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 营养科学 营养科学
背景情况:
- 维生素B12对于胎儿神经发育至关重要.
- 有限的研究综合了母亲的维生素B12状态和补充对儿童神经发育和认知的影响.
- 本综述通过评估相关的临床和观察性研究来弥补这一差距.
研究的目的:
- 系统地评估关于母亲维生素B12补充和状态的临床和观察性研究.
- 评估对儿童神经发育和认知结果的影响.
- 综合当前关于母婴维生素B12与神经发育关系的证据.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 在PubMed,Scopus,Web of Science和Embase数据库中进行了搜索.
- 通过使用Cochrane RoB 2和ROBINS-I工具评估偏差风险.
主要成果:
- 包括11项研究 (4项RCT,7项观察性).
- 母亲补充维生素B12对孩子的认知和语言领域产生积极影响,长达42个月.
- 母亲的维生素B12水平与两岁以下儿童的整体神经发育有关.
结论:
- 怀孕期间母亲的维生素B12状况对于儿童的神经发育很重要.
- 需要进一步的研究,特别是临床试验,以证实这些发现.
- 建议对母体维生素B12进行评估,以减轻潜在的不良神经发育影响.
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