酸银功能化米衍生石墨烯氧化物作为纳米载体,用于pH响应药物输送
Kamal Garwal1, Kundan Singh Rawat2, Tanuja Arya1
1Department of Chemistry, D. S. B. Campus, Prof. Rajendra Singh Nanoscience and Nanotechnology Centre, Kumaun University, Nainital, Uttarakhand, 263001, India.
Discover nano
|December 20, 2025
概括
这项研究开发了一种新的石墨烯氧化物 (GO) 纳米复合物,由米制成,用酸银 (AgNO3) 功能化,并加载了5-甲 (FU). 这种可持续材料通过诱导细胞亡并降低细胞活力,显示出针对性癌症治疗的前景.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 材料化学 材料化学
背景情况:
- 从农业废物中提取的氧化石墨烯 (GO) 为生物医学应用提供了一个可持续的平台.
- 用银酸盐 (AgNO3) 功能化增强了用于药物输送的GO特性.
- 有针对性的癌症治疗需要有效的药物输送系统,副作用最小.
研究的目的:
- 为了合成和描述与酸银 (RH-GO/AgNO3) 功能化的,来自大米的石墨烯氧化物.
- 为了研究RH-GO/AgNO3纳米复合物的pH响应药物释放特征.
- 评估RH-GO/AgNO3的生物医学应用,包括其在充满5 - 甲 (FU) 时用于向癌症治疗的潜力.
主要方法:
- 用AgNO3.3进行GO功能化的化学共沉.
- 药物释放的pH依赖性研究.
- 反应性氧物种 (ROS) 分析和流动细胞测量用于细胞亡和细胞活力评估.
- 用于评估FU载荷的RH-GO/AgNO3.3细胞毒性的MTT试验.
主要成果:
- RH-GO/AgNO3表现出对pH响应的药物释放,与中性pH (7.4) 相比,在酸性pH (4.0) 释放的更高.
- 纳米复合物显著增加了氧化应激,并在HeLa癌细胞中诱导了亡.
- 用FU加载的RH-GO/AgNO3表现出强大的抗癌活性,IC50值低 (256.3μg/mL).
- 治疗导致ROS水平增加,细胞活力降低,癌细胞中亡和亡的增强.
结论:
- 用酸银功能化的米衍生的石墨烯氧化物是一种具有成本效益和可持续的纳米材料,用于先进的药物输送.
- 该RH-GO/AgNO3-FU系统有效诱导癌细胞死亡,主要是通过亡.
- 这项研究强调了农业废物衍生纳米材料在开发新型癌症疗法的潜力.
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