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Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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相关实验视频

Updated: Jan 7, 2026

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
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Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry

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通过Pyxis推进空间-omics,这是用于离子移动性质谱仪成像数据分析的供应商中立软件.

Sara Tortorella1, Sebastian Bessler2, Giuseppe Arturi3

  • 1Mass Analytica SL, Av. Cerdanyola 92-94, 08173, Sant Cugat del Vallés, Spain. sara.tortorella@mass-analytica.com.

Analytical and bioanalytical chemistry
|December 20, 2025
PubMed
概括

质谱成像 (MSI) 产生复杂的数据,但离子流动性 (IM) 谱法有助于分析. 引入了一个新的软件,Pyxis,以克服IM-MSI数据处理对代谢学的挑战.

关键词:
化学测量 化学测量 化学测量离子流动性的离子流动性质谱仪成像成像 质谱仪成像代谢学 代谢学 代谢学软件和数据分析工具.

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相关实验视频

Last Updated: Jan 7, 2026

Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
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科学领域:

  • 分析化学 分析化学
  • 代谢学 代谢学 代谢学
  • 生物技术是生物技术.

背景情况:

  • 质谱成像 (MSI) 能够同时在组织中测量分析物.
  • 复杂的MSI数据集往往含有等离子物种,使分析复杂化.
  • 离子移动性 (IM) 光谱通过提供直角分离维度来增强MSI.

研究的目的:

  • 讨论离子运动质谱成像 (IM-MSI) 数据分析在代谢学中的好处和挑战.
  • 推出Pyxis,这是一个用于IM-MSI数据分析的新型软件解决方案.
  • 用实验数据展示Pyxis的功能.

主要方法:

  • 使用离子运动谱与质谱成像 (IM-MSI) 相结合.
  • 开发并应用Pyxis,这是一个供应商中立的IM-MSI数据分析软件.
  • 分析了来自小鼠脏组织和THP-1单细胞的数据.

主要成果:

  • 对于复杂的MSI数据集,IM-MSI提供了至关重要的直角分离.
  • 在IM-MSI数据分析中的挑战包括数据的复杂性和缺乏全面的软件.
  • Pyxis有效地处理和可视化多维IM-MSI数据.

结论:

  • 在应对数据分析挑战时,IM-MSI是代谢应用的强大技术.
  • Pyxis为整个IM-MSI数据分析工作流提供了一个全面的解决方案.
  • 皮克西斯的证明能力突显了其在推进IM-MSI研究方面的潜力.