在大脑粉样PET中对CortexID和VIZCalc软件进行比较评估:对116例病例进行了回顾性研究
Manduukhai Badarchin1, Yoichi Otomi2, Takayoshi Shinya3
1Department of Radiology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Annals of nuclear medicine
|December 20, 2025
概括
使用CortexID Suite和VIZCalc软件对粉样蛋白PET的量化显示出高的一致性. 这两个平台都可靠地测量粉样蛋白负担,并同意阿尔茨海默病研究的视觉评估.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 生物医学成像技术 生物医学成像技术
背景情况:
- 粉样体正子辐射断层扫描 (PET) 的定量分析对于临床和研究应用至关重要.
- 在不同软件平台上对粉样PET测量的一致性存在不确定性.
- 标准化吸收值比率 (SUVr) 和百分点值是关键的定量指标.
研究的目的:
- 为了比较来自CortexID Suite和VIZCalc的SUVr测量,用于粉样蛋白PET.
- 评估这些测量与专家视觉评估的一致性.
- 评估百叶形值与视觉参考标准的一致性.
主要方法:
- 对116名接受18F-flutemetamolPET扫描的患者进行了回顾性分析.
- 使用CortexID套件和VIZCalc计算SUVr;从VIZCalc获得的百分点值.
- 与核医学医生使用相关性,布兰德-阿尔特曼和ROC分析进行的视觉评估进行比较.
主要成果:
- 来自CortexID和VIZCalc的SUVr值之间存在很强的相关性 (r=0.986).
- 两种平台都显示出与视觉评估的高度一致性 (AUCs ≈0.99).
- 百叶状体值与视觉参考高度一致 (AUC=0.994),与SUVr.相关性良好.
结论:
- 在粉样蛋白负担量化方面,CortexID Suite 和 VIZCalc 具有很高的一致性.
- 这两种软件平台都可以在临床和研究环境中可靠地使用.
- 建议考虑软件特定特征,以保持一致的定量趋势.
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