在发育和衰老过程中,皮下和内脏脂肪的明显前体景观
1Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Cell reports
|December 20, 2025
概括
衰老会减少有益的皮下脂肪组织 (SAT),同时增加有害的内脏脂肪组织 (VAT). 本综述探讨了特定于仓库的脂肪前体细胞差异,驱动这些白色脂肪组织 (WAT) 的变化.
科学领域:
- 脂肪组织生物学 脂肪组织生物学
- 细胞异质性 细胞异质性
- 代谢健康 代谢健康
背景情况:
- 白色脂肪组织 (WAT) 储存能量,皮下 (SAT) 和内脏 (VAT) 储存有不同的代谢作用.
- 增值税与病理学有关,而SAT对代谢有益.
- 老龄化改变了WAT储存,增加了VAT和减少了SAT,但机制仍然不清楚.
研究的目的:
- 在SAT和VAT中审查关于仓库特定脂肪前体异质性的研究.
- 探索新的脂肪前体种群在老化中的SAT和VAT.
- 了解驱动衰老过程中脂肪质量差异变化的机制.
主要方法:
- 对最近关于脂肪前体细胞种群的研究进行文献综述.
- 对调查仓库特异性脂肪组织发育和衰老的研究进行分析.
- 关于细胞异质性及其对脂肪质量的影响的研究结果的综合.
主要成果:
- SAT和VAT在发育起源和前体种群中表现出异质性.
- 衰老与SAT和VAT内的脂肪前体种群的明显变化有关.
- 这些前体细胞的差异有助于在衰老过程中脂肪质量中存储区特定的变化.
结论:
- 了解脂肪前体异质性对于解释衰老过程中WAT的仓库特异性变化至关重要.
- 对这些独特的前体种群的进一步研究可能会揭示与年龄相关的代谢功能障碍的治疗点.
- 准前体细胞机制可以帮助减轻衰老对脂肪组织的负面影响.
关键词:
CP:新陈代谢过程中的新陈代谢.在SAT上,SAT就是SAT.有关增值税的增值税是什么脂肪细胞 (adipocytes) 是一种脂肪细胞.脂肪前体的前体.衰老的衰老 衰老的衰老皮下脂肪组织的脂肪组织.内脏脂肪组织的脂肪组织.更多相关视频
04:46Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
2.2K
08:28Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
Published on: June 30, 2017
9.7K
相关概念视频
01:02Hypodermis
7.2K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.2K
01:29Cholesterol: Significance and Regulation
1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.2K