相关实验视频

Updated: Jan 8, 2026

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

高脂肪饮食促进瘤通过CD155在结肠直肠癌中升级调节的免疫逃避

Liwei Liu¹, Ling Mo², Jingcun Fang¹

¹Department of Oncology and Hematology, He Xian Memorial Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Immunological investigations

|December 20, 2025

概括

高脂肪饮食通过激活STAT3 / CD155通路来恶化癌症免疫疗法,该通路抑制抗瘤免疫力. 针对这个轴可能会提高免疫检查点阻断 (ICB) 治疗在与肥胖相关的癌症中的有效性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
代谢研究研究代谢研究

背景情况:

已知肥胖引起的代谢压力会降低免疫检查点阻塞 (ICB) 疗法的有效性.
高脂肪饮食 (HFD) 促进癌症免疫抑制的确切机制在很大程度上仍未确定.

研究的目的:

阐明HFD的代谢变化如何影响瘤免疫微环境.
调查STAT3/CD155信号通路在调解高血压疾病引起的免疫抑制中的作用.

主要方法:

在正常和HFD条件下使用小鼠结直肠癌模型 (CT26细胞).
进行了抗PD-L1治疗,并分析了瘤生长,免疫细胞透 (流细胞计),蛋白质表达 (西式斑点) 和基因调节 (染色体免疫沉).
研究了STAT3倒置和CD155过度表达效应.

主要成果:

HFD显著降低了抗PD-L1疗法的疗效,导致瘤生长加速.
HFD促进了STAT3核转位和增加了CD155表达,这与减少CD8+T细胞透和增加调控性T细胞积累相关.
STAT3直接与CD155促进体结合,STAT3倒置逆转了HFD诱导的免疫抑制,恢复了抗瘤免疫力.

结论:

来自HFD的代谢压力驱动瘤通过STAT3 / CD155途径进行免疫逃避.
针对STAT3/CD155轴是一个潜在的策略,可以提高ICB在与肥胖相关的癌症中的疗效.

关键词:

CD8+ T 细胞功能障碍有高脂肪的饮食.在STAT3/CD155轴上免疫检查点封锁封锁瘤免疫微环境是一个微环境.

更多相关视频

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...