在 indapamide 的 N-nitrosamine 杂质的立体选择 HPLC 分离和配置稳定性研究

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Updated: Jan 8, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
07:38

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

Published on: September 25, 2017

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Francesca Romana Mammone1, Alessia Panusa1, Marco Pierini2

  • 1Centre for the Control and Evaluation of Medicines, Chemical Medicines Unit, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Journal of chromatography. A
|December 20, 2025
PubMed
概括

这项研究开发了一种HPLC方法,以分离杂质A的四个立体同位素,这是与因达帕米德相关的奇拉性尼托拉胺. 使用特定的基于多糖的奇拉静止相实现了最佳分离,揭示了柱上异构体相互转换.

关键词:
绝对配置的绝对配置动态HPLC的使用方法电子循环二元化是电子循环二元化的.不纯度A 不纯度A 不纯度A伊达帕米德是什么意思N-尼托胺是一种N-nitrosamine.理论上的计算理论上的计算.

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