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Updated: Jan 8, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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通过降低PPARγ/PGC1α/Nrf2的调节,SERCA2功能障碍刺激炎症并导致肺血管重塑

Yixiang Qiu1, Hui Chen1, Yufei Xie1

  • 1School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China.

European journal of pharmacology
|December 20, 2025
PubMed
概括

质体/内质体网膜Ca2+ ATPase 2 (SERCA2) 功能障碍通过促进炎症和氧化应激驱动肺血管重塑. 针对PPARγ等途径可以改善这一过程,为肺高血压提供潜在的治疗方法.

关键词:
在PGC1α中.在PPARγ中,PPARγ是PPARγ这就是 SERCA SERCA.这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.肺动脉平滑肌肉细胞肺动脉平滑肌肉细胞肺高血压是一种肺高血压.肺血管重塑 肺血管重塑

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