新型体积应变能量函数对大动脉压缩能力与光滑肌肉状态的依赖性的建模
Yuxin Zhang1, Yiwen Wang2, Lijie Zhou2
1College of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin, PR China.
Journal of biomechanics
|December 20, 2025
概括
这项研究引入了一种新型模型来量化光滑肌肉状态如何影响大动脉壁的压缩性. 研究结果显示,随着光滑肌肉激活的增加,组织的压缩能力下降,这对血管力学至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 心血管力学 心血管力学
- 计算生物学 计算生物学
背景情况:
- 血管力学对于循环平衡至关重要.
- 目前的模型忽略了光滑肌肉的作用,限制了血管改造模拟的准确性.
研究的目的:
- 量化光滑肌肉状态对大动脉壁压缩能力的影响.
- 为血管生物力学开发一个依赖于状态的模型.
主要方法:
- 提出了一个新的状态依赖的体积应变能量函数模型.
- 利用压力-体积反应实验来描述组织的压缩性.
- 采用双参数对散装模量 (Kx) 和压缩度因子 (α) 的联合校准方案.
主要成果:
- 组织压缩性与光滑肌肉激活有负相关性.
- 放松,正常紧张和收缩状态的确定的参数 (例如,Kr=6.46 MPa,αr=12.73).
- 模型有效地区分了不同光滑肌肉状态的压缩性反应.
结论:
- 这种新型模型为血管生物机械建模提供了多状态策略.
- 为研究血管疾病机制提供了重要的理论价值.
- 通过改善生物力学洞察力,有助于优化内血管治疗设备.
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