在艾滋病患者中长期治疗结果,有或没有 talaromycosis:一个回顾性研究
Dandan Gong1, Weiyin Lin1, Yaozu He1
1Infectious Disease Center, Guangzhou Eighth People's Hospital, Guangzhou Medical, University 510440, Guangzhou, China.
Journal de mycologie medicale
|December 20, 2025
概括
在抗逆转录病毒治疗 (ART) 后,艾滋病患者的长期结果与没有真菌感染的患者相似. 及时启动ART对于改善患有 talaromycosis 的艾滋病患者的预后至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 塔拉罗米科斯是获得性免疫缺陷综合征 (艾滋病) 患者的一种重大机会性感染.
- 抗逆转录病毒疗法 (ART) 是管理艾滋病毒/艾滋病的基石,影响免疫复原和疾病进展.
研究的目的:
- 为了比较艾滋病患者的长期病毒学,免疫学和死亡率的结果,在开始ART后,有或没有 talaromycosis.
- 在ART的背景下,评估 talaromycosis 同感染对免疫复原和生存的影响.
主要方法:
- 在2018年1月至12月期间住院治疗过的艾滋病患者的回顾性研究.
- 评估病毒学结果,免疫反应 (CD4+计数,CD4+/CD8+比率,免疫不响应者) 和在ART启动后五年内死亡率.
- 患有和没有Talaromyces marneffei感染的患者之间的比较.
主要成果:
- 患有塔拉罗米科斯的患者的基线CD4+计数和CD4+/CD8+比率较低.
- 在ART后的60个月内,这两组的CD4+计数和CD4+/CD8+比率均显著改善.
- 病毒抑制率和累积死亡率在五年随访期间,在塔拉罗米科斯和非塔拉罗米科斯组之间是可比的.
结论:
- 抗逆转录病毒疗法对艾滋病患者的免疫复原产生持续的积极影响,不论其 talaromycosis 状态如何.
- 长期的结果,包括免疫恢复和生存,在艾滋病患者中与没有 talaromycosis 的患者相比,并没有劣势.
- 及时启动ART对于优化艾滋病患者的预后至关重要.
相关概念视频
01:29Pulmonary Tuberculosis I
802
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
802
01:28Pulmonary Tuberculosis V
523
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
523
01:28Pulmonary Tuberculosis II
1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K