微塑料和的联合暴露改变了学龄前儿童的肠道微生物群组成:一个横截面研究

微塑料和的联合暴露改变了学龄前儿童的肠道微生物群组成:一个横截面研究

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Chi-Sian Kao¹, Chuen-Bin Jiang², Chih-Chieh Yang¹

¹School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.

Journal of hazardous materials

|December 20, 2025

概括

微塑料 (MP) 和 (Cd) 在儿童中很常见.

科学领域:

环境健康环境健康
微生物组研究微生物组研究
儿科毒理学儿科毒理学

背景情况:

幼儿时期是肠道微生物群发育的关键时期,影响免疫力和神经发育.
儿童的饮食是微塑料 (MP) 和 (Cd) 的主要暴露途径.
对于MPs和Cd对生命早期肠道微生物群的综合影响基本上是未知的.

研究的目的:

调查微塑料和联合暴露与学龄前儿童肠道微生物群组成之间的关联.
测量幼儿便样本中的微塑料和含量.
探索这些共同暴露对特定细菌种群和代谢途径的影响.

主要方法:

分析了68名学龄前儿童 (6岁以下) 的便样本.
微塑料 (MPs) 使用热解气色谱-质谱法 (Py-GC/MS) 来量化.
(Cd) 度使用诱导合血质谱法 (ICP-MS) 进行测量.

主要成果:

在所有便样本中检测到微塑料 (MPs) 和 (Cd).
在便MP和Cd水平之间观察到一个反向的关联.
较低的Cd水平与较高的有益细菌 (例如Bifidobacterium,Faecalibacterium) 的丰度相关.
更高的MP暴露与细菌和相关的代谢功能 (氨基酸,能量,碳水化合物代谢) 的丰富有关.
低Cd-MP和高Cd-MP暴露组都显示出突出的碳水化合物和核酸代谢途径.

结论:

对微塑料和的联合暴露显著改变了学龄前儿童的肠道微生物群.
该研究强调了污染物水平和微生物变化之间的复杂,非单调的关系.
这些发现强调了在早期生命微生物组研究中考虑多种环境污染物的重要性.

关键词:

是的组成部分.便便便便我们的肠道微生物群.微塑料是一种微塑料.幼儿园儿童学龄前儿童

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