运动唤起潜力的空间激活取决于对脉冲跨脑磁刺激的方向和强度
Shokoofeh Parvin1, Joona Juurakko2, Heikki Sinisalo1
1Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
概括
跨磁刺激 (TMS) 的参数,如脉冲方向,强度和间隔,会影响运动唤起潜能 (MEP) 如何激活前臂肌肉. 这项研究使用多线圈TMS (mTMS) 和高密度表面电肌学 (HDsEMG) 来获得精确的神经生理学的见解.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 发动机控制器的控制器
背景情况:
- 跨磁刺激 (TMS) 是研究人类运动皮层的一个关键工具.
- 了解TMS参数如何影响肌肉激活对于准确的神经生理学评估至关重要.
研究的目的:
- 为了研究刺激方向,强度和刺激间隔 (ISI) 在配对脉冲TMS对运动唤起潜能 (MEP) 的空间激活的影响.
- 通过使用先进的TMS和电肌图技术,探索对前臂曲肌肉的影响.
主要方法:
- 使用多线圈TMS (mTMS) 应用配对脉冲TMS范式,以精确电子控制刺激参数.
- 使用高密度表面电肌图 (HDsEMG) 网格记录了电机唤起潜力 (MEP) 的空间激活.
- 刺激在不同的方向 (0°,90°),强度 (70-90% rMT) 和ISIs (0.5 ms,8 ms) 交付.
主要成果:
- 运动唤起潜能 (MEP) 显示在 8 ms ISI 时有促进,在 0.5 ms ISI 时有抑制.
- 改变调节刺激 (CS) 方向,在0.5毫秒ISI下降抑制.
- 增加的CS强度将激活中心体转移到中间;中心体在8 ms时更为中间,在0.5 ms ISI时更为横向.
结论:
- 在TMS中,刺激的方向,强度和ISI系统地调节了前臂肌肉的大小和空间激活模式.
- mTMS和HDsEMG的组合对于探测皮质运动控制的神经生理机制非常有价值,具有潜在的临床应用.
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