在没有中风的心房动中,神经血管合,认知和心脏功能
Songhong Yue1, Jintao Wang2, Jiahao Yan1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China; Second Clinical School, Lanzhou University, Lanzhou 730030, China; Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China.
NeuroImage. Clinical
|December 20, 2025
概括
神经血管合 (NVC) 功能障碍将心脏重塑与没有中风的心房动 (AF) 患者的认知衰退联系在一起. 这种心脑轴障碍为早期干预提供了目标.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 心房动 (AF) 与认知障碍有关,即使没有明显的中风.
- 神经血管合 (NVC) 功能障碍是将AF与认知缺陷联系起来的潜在机制.
- 心脏结构重塑可能会导致AF患者的认知障碍.
研究的目的:
- 调查NVC变化是否调解了无中风AF (sfAF) 患者的心脏重塑和认知缺陷之间的关系.
- 探索心脑轴在与AF相关的认知障碍中的作用.
主要方法:
- 涉及sfAF患者和健康对照的前性队列研究.
- 使用了MRI脑部扫描,心声回声和神经心理评估.
- 使用fMRI指标 (ALFF,fALFF,ReHo,DC) 和区域大脑血流 (CBF) 地图来评估NVC.
- 进行调解分析,以检查NVC,心脏参数和认知之间的关系.
主要成果:
- sfAF患者表现出显著的心脏重塑 (增加LA,LVEDd;减少LVEF) 和较差的认知表现.
- 在sfAF患者中观察到广泛的NVC中断,特别是在下额头环中减少fALFF-CBF合.
- 减少的fALFF-CBF合介导了LVEDd升高和短期记忆障碍之间的关联.
结论:
- 在sfAF中,NVC功能障碍在调解心脏重塑对认知功能的负面影响方面发挥着至关重要的作用.
- 这些发现支持AF中的心脑轴模型,强调NVC是早期干预的潜在治疗目标.
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