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Updated: Jan 8, 2026

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在创伤后应激障碍中,破坏了皮层功能连接和规范的静止状态网络集成

Nick Steele¹, Ahmed Hussain¹, Delin Sun²

¹Brain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.

NeuroImage. Clinical

|December 20, 2025

概括

创伤后应激障碍 (PTSD) 与体功能连接的改变有关. 在患有PTSD的个体中,特定的乳头核显示出明显的休息状态功能连接 (RSFC) 模式,影响感官处理和认知控制.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
功能神经成像功能神经成像

背景情况:

作为一个关键的中继中心的质体具有广泛的皮质连接,但具有不同的亚区域作用.
虽然涉及到创伤后应激障碍 (PTSD),但PTSD中thalamic亚区域的详细分析缺乏.

研究的目的:

在PTSD中调查与皮层和大规模大脑网络的thalamic核的静止状态功能连接 (RSFC).
为了阐明特定的thalamic亚区域对PTSD病理生理学的贡献.

主要方法:

利用来自多个站点数据集的高分辨率功能磁共振成像 (fMRI) 数据.
在397名参与者 (PTSD病例和对照组) 中分析了休息状态功能连接 (RSFC).
研究了与皮层区域和大规模大脑网络的thalamic核的连接模式.

主要成果:

创伤后应激障碍病例显示,肺核和感觉运动/ Salience 区域之间的 RSFC 较弱.
中间生殖细胞核 (MGN) 在PTSD中表现出更强的RSFC与感觉运动皮质.
增加PTSD严重程度与thalamic核 (肺部,中背部) 和皮层感觉/运动区域之间较弱的RSFC相关.
默认模式网络在PTSD中显示出更强的RSFC与中背丘脑.
突出和体感官网络在PTSD中显示出更强的RSFC与体运动体感官核.

结论:

细粒度的胸膜映射显示了PTSD中显著的胸膜皮层干扰.
在PTSD中改变的thalamicRSFC表明转向高度的皮下感官处理和减少自愿控制.
这些发现凸显了研究特定的乳头核对于理解PTSD的重要性.

关键词:

大规模网络的大规模网络.背部中部 thalamus 在此过程中,创伤后应激障碍 (PTSD) 是一种普尔维纳尔 (Pulvinar) 是一个火箭.休息状态的功能连接.塔拉米细胞的核.

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