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在健康开始研究中,妊娠期间的和多基基物质血清度和妊娠期体重增加

Julia R Kaplan¹, Dana Dabelea², Antonia M Calafat³

¹Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

International journal of hygiene and environmental health

|December 20, 2025

概括

暴露于per-和多醇基物质 (PFAS),特别是PFOS和PFHxS,与孕妇的妊娠体重增加有关. 这些关联可能根据怀孕前的体重指数 (BMI) 不同.

科学领域:

环境健康环境健康
生殖健康生殖健康
毒理学毒理学毒理学

背景情况:

和多基基物质 (PFAS) 是无处不在的环境污染物.
暴露于PFAS是妊娠不良结果的潜在风险因素,包括过度妊娠体重增加 (GWG).
之前对PFAS和GWG的研究已经产生了不一致的结果.

研究的目的:

在一组孕妇中调查特定PFAS和GWG血清度之间的关联.
探索妊娠前体重指数 (BMI) 对PFAS-GWG关系的潜在影响修改.

主要方法:

这项研究包括539名来自科罗拉多州健康开始研究 (2009-2014) 的参与者.
在怀孕期间收集的血清中测量了11个PFAS.
孕期体重增加 (GWG) 使用多个指标进行评估,包括绝对体重变化,z-score,第三季度率和医学研究所 (IOM) 分类.
用对共变量调整的回归模型来分析关联,并根据BMI类别评估效果的修改.

主要成果:

perfluorohexane sulfonate (PFHxS) 和 perfluorooctane sulfonate (PFOS) 的血清度与GWG积极相关,并且过度GWG的几率更高.
这些积极的关联在患有超重妊娠前BMI的女性中比患有肥胖或正常/体重不足BMI的女性更为明显.
混合物分析表明,PFOS是观察到的积极关联的主要驱动因素.

结论:

血清中PFOS和PFHxS度与多种不同孕妇群体的GWG增加有关.
PFAS对GWG的影响可能会受到女性怀孕前的BMI状态的影响.
这些发现突显了特定的PFAS在调节GWG中的潜在作用,并表明BMI是修改因素.

关键词:

怀孕期间体重增加.医学研究所的建议医学研究所的建议在PFAS中,有很多方法.和多醇基物质是多和多的.怀孕怀孕怀孕怀孕

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