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克服不可抗药的障碍:以结构为指导的发现,发现了一种具有强大的小分子CD28抗剂,具有转化潜力

Saurabh Upadhyay1, Hossam Nada1, Sungwoo Cho1

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, NY 10065, USA.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|December 20, 2025
PubMed
概括

研究人员开发了一种新的小分子CD28抗剂,BPU11,克服了针对这种免疫检查点的先前限制. 这一突破为小分子免疫疗法提供了一个新的途径,超越了生物药物.

关键词:
CD28辅助刺激受体 CD28辅助刺激受体CD28 小分子抑制剂CD28B7封锁 CD28B7封锁 CD28B7封锁 CD28B7封锁药物动力学概况鉴定 药物动力学概况鉴定

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