来自Hibiscus syriacus的富含安托氨酸的多醇激活了自,以逆转聚乙烯微塑料诱导的骨质功能障碍
Mirissa Hewage Dumindu Kavinda1, Wisurumuni Arachchilage Hasitha Maduranga Karunarathne1, Kyoung Tae Lee2
1Department of Marine Life Science, Jeju National University, Jeju 63243, , Republic of Korea.
概括
希比斯克斯 (Hibiscus syriacus L.) 提取物 (AH) 通过向骨质细胞衰老和自来逆转微塑料诱导的骨损伤. 这种天然化合物对治疗微塑料相关的骨疾病充满希望.
科学领域:
- 环境健康 环境健康
- 骨生物学 骨生物学
- 自然产品治疗药物 自然产品治疗药物
背景情况:
- 微塑料 (MP) 正在环境中积累,对公众健康构成重大威胁.
- 国会议员可以损害骨发育和破坏骨平衡.
研究的目的:
- 调查Hibiscus syriacus L. (AH) 中的富含安东的多是否可以恢复由聚烯微塑料 (PS-MPs) 损害的骨质生成.
- 为了确定AH是否针对骨质细胞衰老和自调节以抵消PS-MP的影响.
主要方法:
- MC3T3-E1骨前细胞被暴露在PS-MP中,并用AH进行治疗.
- 骨质恢复通过性酸酶 (ALP) 活性,矿化和骨质标志物表达来评估.
- 使用分子生物学技术分析了衰老和自标记物. 斑马鱼幼虫作为一个体内模型.
主要成果:
- 暴露于PS-MP降低了骨质原生标志物和增加衰老,表明骨质母细胞功能障碍.
- 治疗AH恢复了ALP活动和矿化,扭转了PS-MP诱导的损害.
- 在斑马鱼中,AH激活了自和改善了脊椎矿化,减少了骨发育不良.
结论:
- 艾希有效地减轻PS-MP诱导的骨质功能障碍.
- 骨质细胞衰老和自细胞激活的双调节是AH治疗潜力的基础.
- AH代表了一种有前途的天然策略,用于对抗微塑料相关的骨疾病.
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