短期和长期暴露于空气污染是否会影响阻塞性睡眠呼吸暂停的风险? 一个系统的审查和元分析
Yansu He1, Shuting Wang1, Tianhang Zhang1
1JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Sleep medicine reviews
|December 20, 2025
概括
空气污染,特别是PM2.5和NO2,与阻塞性睡眠呼吸暂停 (OSA) 严重程度的增加有关. 这次审查发现更高的呼吸暂停-呼吸暂停指数 (AHI) 与更大的暴露于这些污染物.
科学领域:
- 环境健康 环境健康
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,对健康有重大影响.
- 环境空气污染在OSA的发展和恶化中的确切作用仍然不完全理解.
- 确定环境风险因素对于公共卫生干预和OSA管理至关重要.
研究的目的:
- 系统地审查和对空气污染和OSA之间的关联进行现有文献的元分析.
- 评估各种空气污染物 (PM2.5,PM10,NO2,O3) 在不同暴露时间对OSA严重性的影响.
- 为了确定影响空气污染和OSA关系的潜在效果调整者.
主要方法:
- 在PubMed,Web of Science和Embase数据库中进行了全面的系统文献搜索,截至2024年9月.
- 使用固定或随机效应模型进行元分析以合成风险估计,并使用I2统计数据评估异质性.
- 对观察到的关联的证据确定性使用GRADE方法进行了评估.
主要成果:
- 高确定性证据表明,增加短期和长期暴露于PM2.5 (颗粒物≤2.5μm) 会显著增加呼吸暂停-呼吸暂停指数 (AHI).
- 短期和长期暴露于NO2 (二氧化) 也与AHI显著增加有关,由高和中等确定性证据支持.
- 在PM10 (颗粒物≤10μm) 或O3 (臭氧) 暴露和AHI之间没有发现显著的关联,这表明了污染物特定的影响.
结论:
- 暴露于细颗粒物 (PM2.5) 和二氧化 (NO2) 与阻塞性睡眠呼吸暂停的严重程度增加有关.
- 调查结果强调特定的空气污染物是OSA的潜在贡献者,强调需要改善空气质量.
- 进一步的研究可能会探索这些污染物与睡眠呼吸障碍有关的机制,并调查有针对性的干预措施.
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