在EXPANSE项目中,环境暴露对DNA甲基化的影响
Megi Vogli1, Ayoung Jeong2, Zhebin Yu3
1Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
EBioMedicine
|December 20, 2025
概括
诸如空气污染和绿色等城市暴露会影响DNA甲基化,影响所有生命阶段,特别是儿童和成人. 这些环境因素可以影响免疫和癌症途径,突显城市暴露对健康的重要性.
科学领域:
- 环境表观遗传学环境表观遗传学
- 人类健康和寿命延长
- 城市环境健康 城市环境健康
背景情况:
- 城市暴露体,城市环境和社会因素的复杂组合,影响着人口的健康.
- 暴露于城市因素会导致DNA甲基化发生变化,这是一个关键的表观遗传机制.
- 了解这些跨生命周期的联系对于公共卫生至关重要.
研究的目的:
- 调查城市暴露组与表观基因组范围内的DNA甲基化在不同生命阶段之间的关联.
- 确定与DNA甲基化变化相关的特定城市环境因素.
- 探索这些变化对健康相关途径的影响.
主要方法:
- 来自七个欧洲队列 (EXPANSE项目) 的表观基因组广泛关联研究的反变异加权元分析.
- 估计参与者的家庭地址的城市暴露 (空气污染,夜间光线,植被指数,城市化).
- 从儿童,青少年和成人的血液样本中测量DNA甲基化.
主要成果:
- PM2.5,NO2和绿色与儿童的DNA甲基化之间的联系.
- 绿色和城市化与成人DNA甲基化之间的联系.
- 在所有生命阶段识别差异甲基化区域 (DMR).
- 儿童的NO2暴露与免疫和传染病途径有关.
- 成年人的城市化与免疫和癌症途径相关 (PD-L1,PD-1).
结论:
- 城市环境因素在整个生命过程中引发了显著的DNA甲基化变化,在幼儿期和成年期有显著的影响.
- 与其他城市因素相比,绿色显示出明显的甲基化特征.
- 需要进一步的研究来完全解开城市个体暴露的特定甲基组特征.
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