免疫检查点抑制剂诱导的心肌炎:专注于下游的致病成分和潜在的治疗方法
Yifan Chen1, Xuejun Wang2, Yihui Shen2
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai 200032, China; Department of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, 361000, China.
Seminars in cancer biology
|December 20, 2025
概括
免疫检查点抑制剂 (ICI) 提供癌症治疗,但可以引起与免疫相关的不良事件 (irAEs),如心脏炎症 (ICIIM). 这一审查详细介绍了ICIIM的细节.
科学领域:
- 瘤免疫学 瘤免疫学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 彻底改变了癌症治疗,使其适用于大约50%的患者.
- 尽管ICI是有效的,但它可以引发与免疫相关的不良事件 (irAEs),包括潜在的致命性心肌炎 (ICIIM).
- 由于ICI使用增加和诊断能力改善,ICIIM的发病率正在上升.
研究的目的:
- 在ICI治疗的背景下,提供T细胞作用和免疫检查点的概述.
- 将ICIIM的致病过程分为上游,中游和下游阶段.
- 突出最近关于致病机制的研究,重点关注下游组件和治疗策略.
主要方法:
- 审查关于免疫检查点抑制剂和心肌炎的现有文献.
- 将ICIIM病原体分为不同的阶段进行分类.
- 对T细胞功能和免疫检查点路径的分析与ICIIM相关.
主要成果:
- ICI可以导致心肌炎 (ICIIM),这是一个严重的免疫相关不良事件.
- ICIIM的致病过程可以分为三个阶段:上游,中游和下游.
- 研究正在推进推动ICIIM的具体机制,特别是在下游阶段.
结论:
- 了解ICIIM的阶段性病原性对于管理这种不良事件至关重要.
- 专注于下游的致病成分可能会为ICIIM揭示新的治疗点.
- 对ICIIM机制的进一步研究对于改善免疫治疗中的患者安全至关重要.
关键词:
免疫检查点抑制剂 免疫检查点抑制剂在NLRP3炎症酶体中,NLRP3炎症在T细胞,T细胞.巨细胞是什么?巨细胞是什么?线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.肌性心肌炎是一种心肌炎.更多相关视频
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