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产前暴露于紫外线过器和儿童的认知和神经行为发展:一项纵向研究
Tao Ying1, Yao Chen2, Hang Su1
1School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China.
Environmental pollution (Barking, Essex : 1987)
|December 20, 2025
概括
产前暴露于有机紫外线 (UV) 过器可能会对儿童的认知和神经行为发展产生负面影响. 像Oxybenzone这样的特定紫外线过器与较低的智力得分有关,男性的影响更为明显.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 有机紫外线 (UV) 过器在个人护理产品和聚合物中很常见.
- 关于产前紫外线过器暴露及其对儿童神经发育的影响的数据有限.
研究的目的:
- 调查产前紫外线过器暴露与6岁儿童神经发育结果之间的关联.
- 检查紫外线过器对认知和神经行为发展的综合和单独影响.
主要方法:
- 包括393对来自上海-明杭出生队列研究的母子对.
- 在怀孕第三个三个月的母体尿液紫外线过器度量化.
- 评估儿童的认知和神经行为发展,使用韦克斯勒智力量表和儿童行为检查清单.
- 采用线性回归,负二项式回归,贝叶斯核机器回归 (BKMR) 和量子G计算 (QG-C) 模型.
主要成果:
- 氧化 (BP-3) 暴露与较低的全尺度智商系数 (FSIQ),感知推理指数 (PRI) 和口头理解指数 (VCI) 分数有关.
- 较高水平的紫外线过器混合物与FSIQ和PRI相反相关,特别是在男性中.
- 布米特里 (UV-326) 显示出与外部化问题的潜在关联,尽管在不同模型中不一致.
结论:
- 产前紫外线过器暴露可能与儿童认知和神经行为发育受损有关.
- 观察到与紫外线过器暴露相关的神经发育结果的性别特异性脆弱性.
- 需要进一步的研究来证实这些发现,并阐明潜在的生物机制.
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