在临床实践中使用维生素D结合蛋白和25-氧维生素D水平,用于内分泌学家的临床实践
Lingqiong Meng1, Sue A Shapses2, Daniel D Bikle3
1Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ 85004.
概括
由于维生素D结合蛋白 (DBP) 的变化,总的25-氧维生素D (25(OH) D可能不会准确地反映维生素D状态. 在某些临床条件下,自由25 (OH) D可能是一个更好的指标.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 维生素D状态通常使用总25-基维生素D (25(OH) D) 进行评估.
- 维生素D结合蛋白 (DBP) 对维生素D的运输和新陈代谢至关重要.
- DBP水平和结合亲和力可能会有所不同,这可能会影响作为唯一指标的总25(OH) D的准确性.
研究的目的:
- 审查改变DBP度的临床条件,从而改变总的25(OH) D水平.
- 评估这些变化对患者预后的影响.
- 为维生素D状态评估提出替代标志物.
主要方法:
- 对各种临床条件下检查DBP度的研究进行文献综述.
- 分析DBP水平,总数为25...OH) D,与临床结果之间的关系.
- 评估DBP在维生素D代谢物调节和其他生物功能中的作用.
主要成果:
- 在几个生理和临床状态下,DBP度发生变化.
- 这些变化可能会导致总25OH) D和功能维生素D状态之间的差异.
- 除了维生素D的运输之外,DBP还有其他的作用,包括免疫调节和动素清理,从而影响预后.
结论:
- 在某些临床环境中,测量总量25...OH) D可能不足以评估维生素D状态.
- DBP水平的变化具有诊断和治疗方面的影响.
- 在特定的临床条件下,自由25 (OH) D被提议作为一种更准确的维生素D状态的生物标志物.
关键词:
诊断 诊断 诊断 诊断 是一个免费的 25 (((OH) D D 在 25 (((OH) D 中.总共有25个O (OH) D维生素D结合蛋白是一种维生素D结合蛋白.维生素D缺乏症是因为缺乏维生素D.更多相关视频
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