红细胞分布宽度升高是高海拔多细胞病患者慢性山病的指标:一项回顾性研究
Wentao Wu1, Yuenan Ni2, Wenjin Sun3
1Department of High Altitude Medicine, Center for High Altitude Medicine, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, China; High Altitude Medicine Key Laboratory of Sichuan Province, West China School of Medicine and West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, China; Department of Respiratory Care, West China School of Medicine and West China Hospital, Sichuan University, Chengdu, 610041, China.
红细胞分布宽度 (RDW) 升高表明高海拔多细胞血症 (HAPC) 患者的慢性山病 (CMS) 症状. 这种关联在非常高的海拔上更为强烈,这表明RDW是CMS的潜在生物标志物.
科学领域:
- 高度医学 高度医学
- 血液学 血液学 血液学
- 肺部医学 肺部医学
背景情况:
- 慢性山病 (CMS) 的特点是高海拔多细胞血症 (HAPC) 和临床症状.
- 从HAPC过渡到CMS是一个动态的连续.
- 红细胞分布宽度 (RDW) 反映了缺氧,并与高度相关的疾病有关.
研究的目的:
- 调查红细胞分布宽度 (RDW) 和慢性山病 (CMS) 的临床症状在患有高空多细胞血症 (HAPC) 的患者中存在的潜在联系.
主要方法:
- 在十年内对200名HAPC患者进行了回顾性分析.
- 从医疗记录中收集CMS临床症状.
- 应用多变量逻辑回归和受限立方线来分析RDW和CMS症状之间的关系.
主要成果:
- 与非CMS HAPC患者相比,CMS患者的RDW-SD和RDW-CV显著增加.
- 较高的RDW水平预测了CMS症状,在4500米及以上的高度观察到更强的关联.
- RDW-SD显示了与CMS的线性关联整体和在非常高的高度,但在4500m以下的非线性关联.
结论:
- 红细胞分布宽度升高 (RDW) 作为慢性山病 (CMS) 在高海拔多细胞血症 (HAPC) 患者临床症状存在的指标.
- 在居住在极高海拔地区的人群中,RDW和CMS症状之间的关联特别明显.
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