与自杀思想和行为相关的独特和共享的内化和外化遗传因素:来自青少年大脑认知发育研究的发现
Nathaniel S Thomas1, I-Tzu Hung1, Zuriel Ceja2
1Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States of America.
Journal of affective disorders
|December 20, 2025
概括
内化和外化行为的遗传因素对青少年的自杀思想和行为 (STB) 有显著的影响. 这些遗传负债通过行为表型直接和间接地影响性病.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 自杀想法和行为 (STBs) 是儿童和青少年的主要公共卫生问题.
- 内化 (INT) 和外化 (EXT) 行为表型与性病有关,但它们的共同和独特的遗传基础需要进一步调查.
研究的目的:
- 调查内部化和外部化表型对青少年自杀思想和行为 (STBs) 的独特和共同的遗传贡献.
- 探索通过INT和EXT的遗传责任影响STBs的直接和间接途径.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究 (9-14岁) 的数据.
- 基于大规模的全基因组关联研究,为内部化 (INT),外部化 (EXT) 和它们的重叠 (INT-EXT) 构建了多基因分数 (PGS).
- 分析了PGS对性病的直接和间接影响,包括自杀念头 (SI) 和自杀企图 (SA).
主要成果:
- 内化PGS对自杀企图 (SA) 有显著的直接影响.
- 外化PGS显著预测了被动和活跃的自杀念头 (SI).
- INT-EXT PGS显著预测了被动SI,主动SI和SA. 所有通过表型INT和EXT的间接影响都显著.
结论:
- 内部化和外部化行为的遗传责任通过直接的遗传途径和间接的途径,通过行为表型介导,影响青少年的性病.
- 研究结果表明,需要针对青少年内化和外化行为的遗传和表型方面的预防策略.
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