生物活性物质的组装交付:进展,挑战和前景
Yi Hu1, Linfang Zhong1, Pengqi Wang2
1The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, PR China.
Journal of advanced research
|December 20, 2025
概括
组装输送系统 (ADS) 集成自组装和智能材料,用于先进的药物,基因和生物活性剂输送. 这些智能系统提供了精确的定位和响应能力,为个性化医疗铺平了道路.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 组装输送系统 (ADS) 是一种新的药物输送技术,将分子自组装与智能功能材料相结合.
- 与传统系统相比,ADS具有优势,包括可调节的结构,可控制的功能,以及针对性治疗,组织再生和疾病诊断的精确响应能力.
- 尽管它们具有潜力,但对ADS的系统概念化和深入研究仍然有限.
研究的目的:
- 澄清ADS的基本原则,功能特征和多学科应用.
- 阐明ADS的材料设计,自组装机制和交付策略.
- 为开发智能,高效和个性化的临床翻译ADS提供理论支持和技术途径.
主要方法:
- 审查ADS的基本原则和功能特征.
- 对材料设计,自组装机制和交付策略的分析.
- 探索多学科应用和与新兴技术的整合.
主要成果:
- ADS的核心原理涉及分子自组合和刺激响应智能材料的协同集成,用于合理的载体设计.
- 关键优势包括精确的多层次定位,智能响应,多式联动,增强的生物相容性和灵活的工程.
- 在药物输送,组织工程和基因编辑方面取得了突破,有可能用于下一代生物医学应用.
结论:
- ADS提供了一个强大的平台,用于智能和精确的生物活性剂的交付.
- 与人工智能和微流体学的整合加速了下一代ADS的发展.
- ADS对推进个性化医疗和在生物医学应用中建立新的范式具有重大前景.
相关概念视频
01:22Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
152
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
152
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
183
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
183
01:16Drug Delivery: Overview
701
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
701
01:27Bioavailability Enhancement: Drug Permeability Enhancement
176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176
01:16Bioavailability Enhancement: Drug Solubility Enhancement
197
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
197
01:29Microorganisms in Medicine and Therapeutics
914
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
914