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肺外感染Mycobacterium malmoense在一个免疫抑制最小的患者中的感染
Antonios Katsounas1, Gernot Geginat2, Jon S Friedland3
1Department of Medicine, Knappschaft Kliniken - University Hospital Bochum, Ruhr University Bochum, Bochum, Germany; Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.
一种新兴的病原体Mycobacterium malmoense,在一个免疫抑制较小的老年患者中引起了慢性肌炎. 这种罕见的病例凸显了诊断方面的挑战,以及对非结核性真菌菌感染进行量身定制的治疗策略的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 麦尔蒙塞菌 (Mycobacterium malmoense) 是一种新兴的非结核菌 (NTM) 病原体.
- 在严重免疫缺陷的个体中,NTM感染通常会导致肺外疾病.
- 最近的数据表明,在北欧,肺部M. malmoense感染的发病率正在增加.
研究的目的:
- 报告一种异常罕见的,由M. malmoense引起的慢性肌炎病例.
- 突出M. malmoense感染最小免疫抑制个体的潜力.
- 为了强调与M. malmoense感染相关的诊断复杂性和治疗不确定性.
主要方法:
- 组织病理学和培养用于诊断.
- hsp65基因测序用于病原体识别.
- 一个78岁的女性患有紧突炎的临床病例报告.
主要成果:
- 通过组织病理学,培养和基因测序证实了M. malmoense紧症的诊断.
- 患者患有慢性紧张突炎,尽管长期治疗的普雷尼松疗法很少.
- 这种病例代表了一种罕见的临床表现,因为突炎通常影响儿童或严重免疫抑制的成年人.
结论:
- 即使是最小的免疫抑制也可以允许感染缓慢生长的NTM,如M. malmoense.
- 对于M. malmoense感染存在诊断方面的挑战.
- 由于缺乏明确的治疗指南,个性化,多学科的管理是至关重要的.
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