[脂肪性肝病名称的演变:走向范式转变]
1Pôle de médecine interne et maladies infectieuses, hôpital européen Marseille, 6, rue Désirée-Clary, 13003 Marseille, France.
La Revue de medecine interne
|December 20, 2025
概括
脂肪肝疾病的新术语,包括与代谢功能障碍相关的脂肪性肝病 (MASLD),澄清了病因并改善了个性化治疗的患者分层.
科学领域:
- 肝病学和代谢疾病研究.
- 临床命名制度改革. 临床命名制度改革.
背景情况:
- 代谢性脂肪性疾病影响法国人口的16.7%,在2型糖尿病患者中存在明显的重叠.
- 肝硬化症的进展,特别是纤维化,会增加系统性炎症,心血管问题和特定癌症的风险.
- 以前的术语,如NAFLD/NASH没有完全捕捉代谢病因.
研究的目的:
- 引入和定义脂肪性肝病的更新国际命名体系.
- 用更好地反映代谢原因的分类来取代NAFLD和NASH等过时的术语.
- 建立一个改善患者分层和个性化治疗策略的框架.
主要方法:
- 在2023年的国际共识改革中,建立了新的术语.
- 定义的术语包括脂肪性肝病 (SLD),代谢功能障碍相关的脂肪性肝病 (MASLD) 和代谢功能障碍相关的脂肪性肝炎 (MASH).
- 在适度饮酒的MASLD中引入了"代谢性酒精相关肝病 (MetALD) ",同时保留了酒精相关肝病 (ALD) 的定义.
主要成果:
- 改革将"非酒精性脂肪性肝病 (NAFLD) "和"非酒精性脂肪性肝炎 (NASH) "用MASLD和MASH取代.
- 新的分类明确纳入了代谢因素和组织学确认.
- 该框架适应了"密码性肥胖症",并区分了MetALD和ALD.
结论:
- 修订后的命名法增加了关于肝硬化症的代谢基础的清晰度.
- 这种分类有助于将现有数据与新的诊断标准相结合.
- 预计将改善患者分层,为更有针对性和个性化的治疗方法铺平道路.
关键词:
这就是ALD.马夫尔德 (MAFLD) 是一个马什 (MASH) 是一个非常重要的产品.我遇到了ALD.这是NAFLD.纳什·纳什 (Nash Nash) 是一个名为纳什的城市.新的分类是新的分类在 SLD 和 SLD 之间.更多相关视频
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