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对CT/MRI指导的声动力癌症治疗进行系统审查

Daihong Zhou¹, Yao Chen¹, Razzagh Abedi-Firouzjah²

¹Department of Oncology, The First Hospital Affiliated to Army Medical University, Chongqing 400038, China.

Zeitschrift fur medizinische Physik

|December 20, 2025

概括

计算机断层扫描 (CT) 和磁共振成像 (MRI) 引导的声动疗 (SDT) 显示出对非侵入性癌症治疗的前景. 这种方法利用纳米对比剂 (NCAs) 来改善瘤可视化和治疗结果.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
纳米技术纳米技术

背景情况:

声动疗 (SDT) 是一种非侵入性癌症治疗方法,使用超声波激活声敏化剂,产生反应性氧物种 (ROS) 来产生深层组织效应.
由于瘤局部化和实时监测方面的挑战,SDT的临床应用受到阻碍.

研究的目的:

系统地审查CT/MRI引导的SDT使用纳米对比剂 (NCAs) 的临床前进展.
评估这些引导SDT系统的纳米构造设计,成像机制,治疗结果和翻译潜力.

主要方法:

对2015年1月至2025年3月期间发表的研究进行了系统审查.
搜索的数据库包括PubMed,Scopus,Web of Science和谷歌学者,确定了26项符合条件的研究.
数据提取侧重于纳米构造设计,成像,治疗结果和翻译方面.

主要成果:

导向MRI的SDT主要使用加多或基NCAs来增强软组织对比度和实时监测.
通过CT引导的SDT使用高原子数纳米粒子来提高解剖学分辨率.
双模 CT/MRI 平台显示出优异的瘤可视化,增加的 ROS 生产,显著的瘤回归和最小的系统毒性.

结论:

基于CT/MRI指导的SDT代表了精确有效的癌症治疗的有前途的治疗方法.
进一步的临床翻译需要标准化的协议,临床相关的模型和全面的安全评估.

关键词:

癌症癌症癌症癌症计算机断层扫描 (CT) 是一种计算机断层扫描.对比媒介对比媒介.磁共振成像技术磁共振成像技术纳米技术纳米技术声动力学疗法声动力学疗法

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