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多种益生菌对自闭症症状的影响:随机对照试验 (PROBAUT) 的协议

Maja Kotowska-Bąbol¹, Łukasz Konowałek², Hania Szajewska¹

¹Department of Paediatrics, The Medical University of Warsaw, Warsaw, 02-091, Poland.

|December 20, 2025

概括

这项研究调查了12周的益生菌补充剂是否可以减少儿童自闭症谱系障碍 (ASD) 症状. 结果将显示益生菌的益生菌.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
儿科儿科儿科

背景情况:

自闭症谱系障碍 (ASD) 影响全球数百万儿童,影响他们的生活质量.
对ASD研究新型治疗策略至关重要.
益生菌显示出调节肠道微生物群的潜力,并可能缓解ASD症状.

研究的目的:

为了评估12周多种类益生菌补充剂的疗效.
评估对被诊断患有ASD的儿童核心自闭症症状的影响.

主要方法:

一项随机,双盲,安慰剂对照试验,涉及110名患有自闭症的儿童 (7-15岁).
参与者接受了益生菌混合物或安慰剂12周.
主要结局:自闭症症状评分表 (ASRS);次要结局:生活质量,睡眠,父母压力,胃肠道症状,尿路p-cresol.

主要成果:

将收集自闭症症状评级尺度 (ASRS) 的初级结果数据.
将分析关于生活质量,睡眠,父母压力,胃肠道症状和尿路p-cresol的二次结果数据.
所有评估将在基线和12周干预期后进行.

结论:

这项研究将提供有关益生菌作为ASD辅助疗法的潜力的见解.
这些发现可能会为未来的研究和临床实践提供有关ASD肠道微生物群调节的信息.
结果将通过同行评审的出版物和科学会议传播.

关键词:

自闭症谱系障碍自闭症谱系障碍益生菌益生菌益生菌生活质量生活的质量.

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