哺乳动物和鸟类的冷和TRPM8依赖的震动
Tudor Selescu1,2, Ramona-Andreea Bivoleanu3, Violeta-Maria Caragea3
1Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania. tudor.selescu@bio.unibuc.ro.
Communications biology
|December 20, 2025
概括
动物掉冷水来调节体温. 这项研究表明,TRPM8 (过渡受体潜力 melastatin 8) 通道对于哺乳动物和鸟类的湿气诱导的动行为至关重要,这表明了融合进化.
科学领域:
- 比较生理学比较生理学
- 神经科学是一个神经科学.
- 进化生物学是进化的生物学.
背景情况:
- 内热动物使用温度调节来维持体温.
- 从毛皮或羽毛中去除冷水有助于温度调节.
- "湿狗摇" (WDS) 行为在哺乳动物中是已知的,但在鸟类中研究较少.
研究的目的:
- 调查TRPM8 (过渡受体潜力 melastatin 8) 在潮湿诱导的震动行为中的作用.
- 为了确定TRPM8是否在哺乳动物和鸟类中调解冷湿感应.
- 探索白魔会行为的进化基础.
主要方法:
- 给动物和鸟类使用新型TRPM8激动剂.
- 观察激动剂和喷水诱导的震动行为.
- 在喷水小鼠中评估TRPM8-依赖的WDS发病情况.
主要成果:
- 一个TRPM8激动剂在动物和鸟类中诱导了WDS,模仿喷水.
- TRPM8对于喷水小鼠中WDS的出现至关重要.
- 证据支持TRPM8对被测试物种中的WDS行为依赖.
结论:
- 在哺乳动物和鸟类中,TRPM8参与冷湿感应.
- 在这些物种中,WDS对冷湿的反应行为是TRPM8-依赖的.
- 融合进化很可能选择了类似的动行为来排出水,涉及TRPM8.
相关概念视频
Thermosensation
33.5K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.5K
Decreased Body Temperature
952
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
952
Responses to Heat and Cold Stress
14.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.6K


