心脏代谢指数 (CMI) 与阻塞性睡眠呼吸暂停的风险增加有关:基于人口的研究
Xinyi Chen1,2, Yueyu Zhang1,2, Yu Wang1,3
1Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People's Hospital), Hefei, 230011, Anhui, People's Republic of China.
European journal of medical research
|December 20, 2025
概括
心脏代谢指数 (CMI) 与阻塞性睡眠呼吸暂停 (OSA) 风险有关,特别是在有代谢障碍的人群中. 较高的CMI水平与增加的OSA风险相关,这表明CMI水平.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 代谢健康 代谢健康
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与心脏代谢异常密切相关.
- 综合性心脏代谢指数 (CMI) 对OSA风险分层的有用性尚未得到充分证实.
研究的目的:
- 为了研究心脏代谢指数 (CMI) 与阻塞性睡眠呼吸暂停 (OSA) 风险之间的关联,在一大群人群中.
主要方法:
- 利用了39722名参与国家健康和营养检查调查 (NHANES) 的数据.
- 根据自我报告的症状定义OSA;使用后勤回归,细分回归和非线性模型分析CMI和OSA关联.
- 员工倾向分数匹配 (PSM) 和子组分析用于结果验证和异质性评估.
主要成果:
- 较高的CMI显示出与OSA风险有显著的非线性正相关性,其特征是"反转的L形"关系.
- 与最低四分位数 (Q1) 相比,最高CMI四分位数 (Q4) 显示OSA风险明显更高 (OR=1.272,P<0.001).
- 这种联系在年轻人,女性以及没有高血压或中风的人中更为明显.
结论:
- 心脏代谢指数 (CMI) 是阻塞性睡眠呼吸暂停 (OSA) 风险的有价值的非线性预测指标.
- 在有代谢障碍的人群中,CMI可以作为早期OSA查的实用工具.
- 这些发现支持新的公共卫生干预措施和OSA临床风险评估策略.
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