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Updated: Jan 7, 2026

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由致病突变引起的改变PTPN13-β-catenin相互作用以及该轴参与B细胞受体信号传递

David A Cabrera-Riofrío1,2, Hongbing Li3, Clara García-Calvo1,2

  • 1Departamento de Bioquímica y Biología Molecular, Universidad de Salamanca, Plaza Doctores de la Reina, s/n, Salamanca, 37007, Spain.

Scientific reports
|December 20, 2025
PubMed
概括

蛋白氨酸酸酶非受体13型 (PTPN13) 突变破坏其与β-catenin的相互作用,影响B细胞受体信号传递. 这种干扰有助于淋巴细胞异常和潜在的血液学疾病.

关键词:
急性淋巴细胞白血病 (ALL)B细胞受体 (BCR) 是一种B细胞受体.布鲁顿氨酸激酶 (BTK) 是一种遗传性骨髓衰竭 (IBMF) 是一种疾病.在PTPN13中使用.这是一种β-catenin.

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