封装益生菌和纳米益生菌 - 生物相容材料,加工技术和应用:一篇综述
Abrar Hussain1, Warisha Alvi1, Hesham R El-Seedi2
1Third World Center for Science and Technology, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Biomolecules & biomedicine
|December 21, 2025
概括
使用微型和纳米封装技术进行益生菌封装,显著提高了细菌的生存率和向传递. 这一战略克服了加工和消化方面的挑战,改善了功能性食品的应用.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 益生菌的有效性取决于向目标部位提供足够的可活细胞 (~106-107 CFU/g或mL).
- 工业加工,储存和胃肠道条件往往会降低益生菌的活力,低于有效水平.
研究的目的:
- 审查微型和纳米封装策略,以提高益生菌的活力和受控释放.
- 分析封装材料和技术,以改善食品和生物医学应用中的交付.
主要方法:
- 对天然多糖类 (酸盐,奇托,点,粉) 和蛋白质 (素/乳清) 的文献综合和分析.
- 检查封装技术:挤出,乳化,喷雾干燥,冷干燥,电,凝聚.
- 专注于释放机制,食品矩阵兼容性和对环境压力的保护.
主要成果:
- 与自由益生菌相比,封装显著提高了对酸,胆,氧,热和脱水的抵抗力.
- 在各种封装方法中观察到增强的存储稳定性和减少的可行性损失.
- 多层和纳米系统证明了更好的保护和有针对性的肠道/结肠释放.
结论:
- 封装益生菌为功能性食品和生物医学输送系统提供了一个有前途的平台.
- 过程引起的损害,过早释放,感官影响,成本,可扩展性和监管标准化仍然是挑战.
- 未来的研究应该集中在对刺激有反应的材料,自动化制造和先进的功能验证上.
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